Cd19 Mouse Monoclonal Antibody [Clone ID: MRQ-36]

Specifications

Product Data
Clone Name	MRQ-36
Applications	IHC
Recommend Dilution	IHC: 1:25 - 1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Isotype	IgG1, kappa
Formulation	This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	CD19 antigen
Database Link	NP_033974 Entrez Gene 930 Human UniProt ID P25918
Synonyms	B4; Leu-12; MGC12802
Note	CD19 is present in both benign and malignant B-cells and has long been considered to be the most reliable surface marker of this lineage over a wide range of maturational stages. In normal lymphoid tissue, CD19 is observed in germinal centers, in mantle zone cells, and in scattered cells of the interfollicular areas. Anti-CD19 exhibits an overall immunoreactivity pattern similar to those of the antibodies against CD20 and CD22. However, in contrast to CD20, CD19 is also expressed in immature B-cells. Recently, Masir et al. have described the expression of CD19 in normal lymphoid tissue and its loss in B-cell neoplasms.Anti-CD19 positivity is seen in the vast majority of B-cell neoplasms commonly at a lower intensity than normal B-cell counterparts. Plasma cell neoplasms are nearly always negative, as are T-cell neoplasms.
Reference Data

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