CD63 Mouse Monoclonal Antibody [Clone ID: NKI/C3]

Specifications

Product Data
Clone Name	NKI/C3
Applications	IHC
Recommend Dilution	IHC: 1:100 - 1:500
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Isotype	IgG1, kappa
Formulation	This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	CD63 molecule
Database Link	NP_001244318 Entrez Gene 967 Human UniProt ID P08962
Synonyms	LAMP-3; ME491; MLA1; OMA81H; TSPAN30
Note	This antibody reacts with a 53 kDa protein which forms a part of the family of tetraspan moieties. The antigen was originally designated as a lysosomal membrane protein characterized as an activation dependent platelet surface antigen. In fact the CD63 antigen has a diverse distribution on the surface and in the cytoplasm of many cell types including lymphoid, myeloid, endothelial cells, and melanoma. It has been quite useful in identifying malignant melanoma. It has also been reported as useful in differentiating renal oncocytoma (apical and/or polar staining pattern) from eosinophilic renal cell carcinoma (diffuse cytoplasmic staining pattern). CD63 is well expressed in tissue mast cells in the lung, skin, and bone marrow. It can be overexpressed on the surface of neoplastic mast cells in aggressive systemic mastocytosis although it is less expressed in indolent systemic mastocytosis.
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Lysosome

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