KAP1 (TRIM28) Mouse Monoclonal Antibody [Clone ID: 20A1]

Specifications

Product Data
Clone Name	20A1
Applications	IF, WB
Recommend Dilution	WB, IF, ChIP
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Not provided
Isotype	IgG1, kappa
Formulation	This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml.
Concentration	lot specific
Purification	The antibody was purified by affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	110 kD
Gene Name	tripartite motif containing 28
Database Link	NP_005753 Entrez Gene 10155 Human UniProt ID Q13263
Background	TIFβ (transcription intermediary factor 1-beta) is an 88 kD member of the tripartite motif family. This protein contains three zinc binding domains, a RING domain, a B-box type 1 and type 2 domain, and a coiled-coil region. TIFβ is found in the nucleus and associates with specific chromatin regions. This protein forms a complex with KRAB-domain transcription factors and recruits setdbl to histone 3 to increase KRAB-mediated transcriptional repression. TIF1β has been reported to interact with setdbl and cbx3 proteins. Studies using knockout mice reveal the important function of TIF1β in regulating genomic imprinting, T cell activation, and T cell tolerance.
Synonyms	KAP1; PPP1R157; RNF96; TF1B; TIF1B
Reference Data
Protein Families	Protein Kinase, Stem cell - Pluripotency, Transcription Factors

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