CD46 Rat Monoclonal Antibody [Clone ID: TUG8]

Specifications

Product Data
Clone Name	TUG8
Applications	WB
Recommend Dilution	WB
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Recombinant GST-mouse mMCP-8 fusion protein expressed in E.coli
Isotype	IgG2a
Formulation	Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Concentration	lot specific
Purification	The antibody was purified by affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	CD46 molecule
Database Link	NP_758860 Entrez Gene 4179 Human UniProt ID P15529
Background	mMCP-8 and its rat homologues, rMCP-8, -9, and -10, form a new group of mast cell/basophil proteases, which are more closely related to the T-cell granzymes and neutrophil cathepsin G than to the mast cell tryptases and chymases. mMCP-8 showed a high degree of homology with mouse granzyme B in the critical regions for determining substrate cleavage specificity. It preferentially cleaves after Asp residues. mMCP-8 mRNA is highly expressed in a mouse connective tissue MC-like tumor line. However, it could not be detected in mouse liver, intestine, lung or ears, indicating very low expression in normal tissues. A strong increase in mMCP-8 levels in the lungs can be detected in infected animals.
Synonyms	AHUS2; MCP; MIC10; TLX; TRA2.10
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Complement and coagulation cascades

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