PRR6 (CENPV) Rat Monoclonal Antibody [Clone ID: Cas11.17D9]

Specifications

Product Data
Clone Name	Cas11.17D9
Applications	WB
Recommend Dilution	WB
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	His tagged bacterial fusion protein of p 30 of caspase 11
Isotype	IgG2a
Formulation	Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Concentration	lot specific
Purification	The antibody was purified by affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	centromere protein V
Database Link	NP_859067 Entrez Gene 201161 Human UniProt ID Q7Z7K6
Background	Murine caspase-11 is an upstream protease of caspase-1 and interacts with the proform of caspase-1 which in turn activates IL-1 beta. Caspase-11 is not constitutively expressed in most cell types. Its expression can be upregulated by LPS, IFN-gamma, and other pro-inflammatory stimuli. NF-κB and STAT1 were reported to be involved in the activation. Caspase-11 knock -out mice were resistant to endotoxin shock and do not produce IL-1 after stimulation with LPS. Their production of IFN-gamma was also deficient.
Synonyms	3110013H01Rik; CENP-V; p30; PRR6
Reference Data

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