Gjb2 Rabbit Polyclonal Antibody

CAT#: TA328775

Rabbit Polyclonal Anti-Connexin-26



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CNY 11,000.00


货期*
7周

规格
    • 50 ul

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Specifications

Product Data
Applications IF, WB
Recommend Dilution WB: 1:200-1:2000; FC: 1:50-1:600
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Peptide (C)HEKKRKFMKGEIK, corresponding to amino acid residues 100-112 of rat Connexin-26. Intracellular, cytoplasmic loop.
Formulation Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification Affinity purified on immobilized antigen.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name gap junction protein, beta 2
Background Connexins (Cx) are integral membrane proteins consisting of four transmembrane domains, two extracellular loops, one intracellular loop and intracellular N- and C-termini. The 21 members belonging to this family form homomeric or heteromeric hexamers generally termed connexons or hemi-channels. In turn, these hemi-channels further assemble in a head-to-head manner, thus forming gap junction channels. Connexins are ubiquitously expressed and their activity is regulated at the expression level and by post-translational modifications. Gap junctions are usually found in clusters and enable intercellular communication by allowing the passage of small molecules between cells. They play important roles in different biological processes. These include differentiation, cell cycle synchronization, cellular development, neuronal activity and the immune response. Due to their important roles, mutations in connexins are linked with a number of diseases such as neurodegenerative disorders, skin diseases and developmental abnormalities. Mutations in the gene encoding for Connexin-26 protein are associated with deafness.
Synonyms Connexin-26; CX26; DFNA3; DFNA3A; DFNB1; DFNB1A; HID; KID; NSRD1; OTTHUMP00000018094; PPK
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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