Gabrg2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide QKSDDDYEDYASNKT(C), corresponding to amino acid residues 39-53 of rat GABA(A) ?2 Receptor. Extracellular, N-terminus.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	gamma-aminobutyric acid type A receptor gamma 2 subunit
Database Link	NP_899156 Entrez Gene 2566 HumanEntrez Gene 14406 MouseEntrez Gene 29709 Rat UniProt ID P18508
Background	The neurotransmitter GABA (?-aminobutyric acid) inhibits the activity of signal-receiving neurons by interacting with the GABAA receptor on these cells.1 There are two major types of GABA receptors: the ionotropic GABAA (GABAA R) and the metabotropic GABAB receptors.GABAA R belongs to the ligand gated ion channel superfamily.It is a heteropentamer, with all of its five subunits contributing to the pore formation. To date, eight subunit isoforms were cloned: a, Ã?, ?, d, e, p, ?, and ?.The native GABAA receptor, in most cases, consists of 2a, 2Ã? and 1? subunit. Three ? subunits genes have been identified in mammals. The binding of GABA to its GABAA receptor results in conformational changes that open a Cl- channel, producing an increase in membrane conductance, resulting in inhibition of neural activity.Recently, a genetic linkage between familial epilepsy syndrome and mutations in the ?2 subunit of the GABAA receptor have been demonstrated.
Synonyms	CAE2; ECA2; GEFSP3
Note	This antibody was tested in live cell imaging. Please see IF/ICC data for detail.
Reference Data

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