Mineralocorticoid Receptor (NR3C2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-NR3C2 antibody: synthetic peptide directed towards the N terminal of human NR3C2. Synthetic peptide located within the following region: METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSC
Isotype	IgG
Formulation	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	107 kDa
Gene Name	nuclear receptor subfamily 3 group C member 2
Database Link	NP_000892 Entrez Gene 4306 Human UniProt ID P08235
Background	This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Synonyms	MCR; MLR; MR; NR3C2VIT
Note	Immunogen sequence homology: Horse: 100%; Human: 100%; Dog: 93%; Rabbit: 86%; Pig: 79%; Rat: 79%; Mouse: 79%; Bovine: 77%
Reference Data
Protein Families	Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

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