53BP1 (TP53BP1) Rabbit Polyclonal Antibody
CAT#: TA332891S
Rabbit anti-TP53BP1 Polyclonal Antibody
Size: 100 ul
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CNY 800.00
货期*
2周
规格
Specifications
Product Data | |
Applications | ELISA, IHC, WB |
Recommend Dilution | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Formulation | Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20℃. Avoid freeze / thaw cycles. |
Predicted Protein Size | 214kDa |
Gene Name | tumor protein p53 binding protein 1 |
Database Link | |
Background | This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Synonyms | 53BP1; p202 |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
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