MITF Mouse Monoclonal Antibody [Clone ID: 21D1418]

Specifications

Product Data
Clone Name	21D1418
Applications	ICC/IF, IHC, WB
Recommend Dilution	Immunocytochemistry/ Immunofluorescence: 1-5 ug/ml, Immunohistochemistry-Paraffin: 1:200, Immunohistochemistry: 1:200, Western Blot: 0.1 - 1.0 ug/ml
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	A synthetic peptide mapping to the 400-450 a.a. region of accession number O75030.
Isotype	IgG1
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	melanogenesis associated transcription factor
Database Link	NP_937821 Entrez Gene 17342 MouseEntrez Gene 25094 RatEntrez Gene 4286 Human UniProt ID O75030
Background	Microphthalmia-associated bHLH-LZ transcription factor (Mitf) is a positively acting transcription factor containing a transcription activation domain and a bHLH-LZ domain that mediates DNA-binding and dimerization. Both the transcription activation and bHLH-LZ domains are highly conserved in the closely related TFE3, TFEB and TFEC transcription factors. Mitf can form heterodimers in vitro with the above transcription factors, but not with other bHLH-LZ factors such as Myc, Max or USF. Mitf is expressed as multiple isoforms, which share common transcription activation and DNA-binding domains, but differ in the amino-terminal region. Mitf is targeted by three kinases: GSK-3beta, Map kinase ERK2 and members of the p90 Rsk family of kinases.
Synonyms	bHLHe32; CMM8; MI; WS2; WS2A
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Melanogenesis, Melanoma, Pathways in cancer

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