TRF2 (TERF2) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ChIP, FC, ICC/IF, IHC, IP, WB
Recommend Dilution	Immunoprecipitation: 2 ug/ 10^6 cells, Western Blot: 2 ug/ml, Immunohistochemistry-Paraffin: 15 ug/ml, Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Immunohistochemistry: 1:10-1:500, Flow Cytometry, Knockdown Validated, Chromatin Immunoprecipitation (ChIP): 1:20-1:1000
Reactivity	Human, Mouse
Host	Goat
Clonality	Polyclonal
Immunogen	Baculovirus expressed His-tagged whole length TRF2 protein was used for immunizing goat (NP_005643).
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	telomeric repeat binding factor 2
Database Link	NP_005643 Entrez Gene 21750 MouseEntrez Gene 7014 Human UniProt ID Q15554
Background	TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
Synonyms	TRBF2; TRF2
Reference Data
Protein Families	Transcription Factors

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