TRAF2 Mouse Monoclonal Antibody [Clone ID: 33A1293]

Specifications

Product Data
Clone Name	33A1293
Applications	IHC, WB
Recommend Dilution	Western Blot: 2 ug/ml, Immunohistochemistry: 2:20-2:1000, Immunohistochemistry-Paraffin: 1:10-1:500
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Anti-TRAF2 monoclonal antibody was raised against a fusion protein corresponding to amino acids 205 to 222 of human TRAF2.
Isotype	IgG1, kappa
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	TNF receptor associated factor 2
Database Link	NP_066961 Entrez Gene 7186 Human UniProt ID Q12933
Background	Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). TRAF2 is a 502-amino acid protein. Mutagenic studies suggest that the N-terminal RING finger and two adjacent zinc fingers of TRAF2 are required for NF-kB activation, where as interaction with TNFR is mediated through C-terminus domain. Distinct domains in the N- and -C termini are also required for association with TRAF1 and protein kinase receptor interacting protein (RIP). TRAF2 is involved in cellular resistant to TNF-induced apoptosis. TRAF-2 deficient mice appeared normal at birth, however, they die prematurely, probably due to atrophy of thymus, spleen, muscle mass and lack of TRAF-2's cytoprotective role.
Synonyms	MGC:45012; TRAP; TRAP3
Note	Useful in Immunohistochemistry-Paraffin See Galen et al (2008)
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Adipocytokine signaling pathway, Apoptosis, MAPK signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer

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