TIRAP Mouse Monoclonal Antibody [Clone ID: 20D1055.1]

Specifications

Product Data
Clone Name	20D1055.1
Applications	WB
Recommend Dilution	Western Blot: 1:500-1:1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	This antibody was developed against a synthetic peptide corresponding to a portion of human TIRAP.
Isotype	IgM, kappa
Formulation	Preservative: 0.05% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Ascites
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Database Link	NP_001034750 Entrez Gene 114609 Human UniProt ID P58753
Background	The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). TIRAP (TIR domain-containing adaptor protein) is an adaptor protein used by TLR4. Blocking TIRAP inhibits TLR4-mediated signaling events, including DC maturation and cytokine production (4). It has 235 amino acids and is commonly seen as a 32-37 kD protein (4).
Synonyms	BACTS1; Mal; MyD88-2; wyatt
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Toll-like receptor signaling pathway

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