NFAT2 (NFATC1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, Simple Western, WB
Recommend Dilution	Simple Western: 1:100, Immunocytochemistry/ Immunofluorescence: 1:20, Western Blot: 1-3 ug/ml, Immunohistochemistry
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Amino acids 264-282 (NKRKYSLNGRQPPYSPHHS) of human NFATc1 were used as immunogen for this antibody.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	nuclear factor of activated T-cells 1
Database Link	NP_765976 Entrez Gene 18018 MouseEntrez Gene 4772 Human UniProt ID O95644
Background	NFAT (nuclear factor of activated T cell) transcription factors play critical roles in gene transcription during immune responses. The NFAT complex is made up of NFATc (NFATc1 - 4) and AP-1 transcription factor. NFAT proteins are regulated by Ca2+. NFATc1 is a substrate protein phosphatase calcineurin, a critical mediator of calcium signals during Tcell activation. NFATc1 activation requires the translocation of the transcription factor into the nucleus, a process that is mediated by calcineurin.
Synonyms	NF-ATC; NF-ATc1.2; NFAT2; NFATc
Note	Immunoreative bands can be blocked by preincubation of NB100-56732 with immunizing peptide. The NFATc1 antibody may detect multiple isoforms of different sizes depending upon testing material.
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Axon guidance, B cell receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, VEGF signaling pathway, Wnt signaling pathway

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