DISC1 Rabbit Polyclonal Antibody

CAT#: TA336518

Rabbit Polyclonal DISC1 Antibody



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CNY 5,381.00


货期*
5周

规格
    • 100 ul

Product images

经常一起买 (5)
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Recombinant protein of human disrupted in schizophrenia 1 (DISC1), transcript variant L, 20 µg
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Transient overexpression lysate of disrupted in schizophrenia 1 (DISC1), transcript variant q
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Recombinant protein of human disrupted in schizophrenia 1 (DISC1), transcript variant L, 100 µg
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Transient overexpression lysate of disrupted in schizophrenia 1 (DISC1), transcript variant L
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Specifications

Product Data
Applications ICC/IF, IHC
Recommend Dilution Immunohistochemistry-Frozen, Immunohistochemistry: 2.5-5.0 ug/ml, Immunocytochemistry/ Immunofluorescence: 1:100, Immunohistochemistry-Paraffin: 2.5-5ug/ml
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide made to an internal region (within residues 700-800) of the mouse DISC1 protein. [Swiss-Prot# Q811T9]
Formulation Tris-glycine, 150 mM NaCl, 0.05% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Immunogen affinity purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name disrupted in schizophrenia 1
Background DISC1 (Disrupted in Schizophrenia 1) is a well known risk genes for psychiatric disorders including schizophrenia, major depression, bipolar disorder, and autism. DISC1 protein localize to cytoskeleton-rich regions in cells, including the centrosome, base of primary cilia, axon and dendritic shafts and spines. For serving its multiple functions, DISC1 interacts with CCDC88A, GSK3B, PCNT, tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, NDEL1, PAFAH1B1, RANBP9, SPTBN4, SYNE1, TRAF3IP1, CHCHD6 and NDEL1. DISC1 interaction with microtubules TRAF3IP1. In neurogenesis regulation, DISC1 is essential for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development as well as in adult dentate gyrus of hippocampus. DISC1 modulates GSK3Beta activity and CTNNB1 abundance for acting as positive regulator of WNT-mediated neural progenitor proliferation. DISC1 can modulate AKT-mTOR signaling for controlling the neuron positioning, dendritic development and synapse formation which ultimately regulate newborn neurons integration during adult neurogenesis and can regulate the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Moreover, DISC1 is implicated in microtubule network formation, regulation of functional biology of centrosome as well as primary cilia, neuronal migration and microtubule mediated transport.
Synonyms C1orf136; SCZD9
Note This DISC1 antibody is useful for Immunocytochemistry/Immunofluorescence and Immunohistochemistry paraffin embedded sections. Use in Immunohistochemistry-Frozen reported in scientific literature (PMID 24560582) The theoretical molecular weight of DISC1 is ~90 kDa. Preliminary Western Blot studies have been performed with this antibody, where several non-specific bands are seen. Due to alternative splicing, DISC1 may also run at ~75 and 100 kDa. In ICC/IF, cytoplasmic staining was observed in PC12 cells.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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