c-Myc (MYC) Mouse Monoclonal Antibody [Clone ID: 9E10]
CAT#: TA336685
Mouse Monoclonal c-Myc Antibody (9E10)
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CNY 5,381.00
Cited in 1 publication. |
CNY 3,080.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
CNY 9,998.00
Specifications
Product Data | |
Clone Name | 9E10 |
Applications | ChIP, ELISA, FC, ICC/IF, IHC, Immunoblotting, IP, Sandwich ELISA, Simple Western, WB |
Recommend Dilution | Flow (Intracellular), Chromatin Immunoprecipitation (ChIP), Immunoblotting, Sandwich ELISA, Flow Cytometry: 1:50-1:200, Proximity Ligation Assay, Immunohistochemistry-Paraffin: 1:50-1:200, Immunohistochemistry-Frozen: 1:50-1:200, Western Blot: 0.5-2.0 ug/ml, Simple Western: 1:200, ELISA: 1:100-1:2000, Immunohistochemistry: 1:50-1:200, Immunocytochemistry/ Immunofluorescence: 1:50-1:200, Immunoprecipitation: 1:10-1:500 |
Reactivity | Human, Mouse, Drosophila |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | A synthetic peptide corresponding to amino acids 408-439 (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) of human c-Myc. [UniProt# P01106] |
Formulation | PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Concentration | lot specific |
Purification | Protein G purified |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | v-myc avian myelocytomatosis viral oncogene homolog |
Database Link | |
Background | Myc genes are a family of proto-oncogenes (L- Myc, N- Myc and C- Myc) that codes for Myc proteins which are transcriptor factors implicated in cellular proliferation, differentiation, apoptosis, metabolism, adhesion and self-renovation of tumor stem cells. Myc protein can act as transcriptional activator/repressor, and is activated via response to diverse mitogenic signals (including Wnt, Shh and EGF) and has been found to be up-regulated in several types of cancers. c-Myc participates gene transcription regulation and binds DNA in a non-specific manner, yet can specifically recognizes core sequence 5'-CAC[GA]TG-3' also. c-Myc heterodimerization with another bHLH protein namely Myc-associated factor X (MAX) is required for efficient c-Myc- DNA binding. c-Myc interacts with several proteins such as TAF1C, SPAG9, PARP10, KDM5A, KDM5B, NO66, PIM2 and with FBXW7 when phosphorylated at Thr-58/Ser-62. c-Myc activate the transcription of growth-related genes and c- Myc overexpression induce cell-cycle progression thereby implicating in a variety of cancers. Moreover, a chromosomal aberration involving c-Myc has been linked to a form of B-cell chronic lymphocytic leukemia and defective c-MYC is responsible for Burkitt lymphoma also. |
Synonyms | bHLHe39; c-Myc; MRTL; MYCC |
Note | This c-Myc antibody clone 9E10 is useful for Flow Cytometry (PMID: 21315712), Western Blot, ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin and Immunoprecipitation. |
Reference Data | |
Protein Families | Druggable Genome, Embryonic stem cells, Induced pluripotent stem cells, Stem cell - Pluripotency, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - TGFb/BMP signaling pathway, Stem cell relevant signaling - Wnt Signaling pathway, Transcription Factors |
Protein Pathways | Acute myeloid leukemia, Bladder cancer, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Jak-STAT signaling pathway, MAPK signaling pathway, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway, Thyroid cancer, Wnt signaling pathway |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
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Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling
,Teratani, T;Tomita, K;Toma-Fukai, S;Nakamura, Y;Itoh, T;Shimizu, H;Shiraishi, Y;Sugihara, N;Higashiyama, M;Shimizu, T;Inoue, I;Takenaka, Y;Hokari, R;Adachi, T;Shimizu, T;Miura, S;Kanai, T;,
Free Radic. Biol. Med.
,PubMed ID 32553752
[MYC]
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