ATF3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1:100-1:2000, Western Blot: 1:200, Immunohistochemistry-Paraffin: 5 ug/ml, Immunohistochemistry: 5 ug/ml
Reactivity	Human, Mouse, Rat, Mammalian
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to a region of human ATF3 (within residues 100-150). [UniProt# P18847]
Formulation	PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	17 kDa
Gene Name	activating transcription factor 3
Database Link	NP_004015 Entrez Gene 11910 MouseEntrez Gene 25389 RatEntrez Gene 467 Human UniProt ID P18847
Background	ATF3 (activating transcription factor 3) belongs to ATF/CREB family of transcription factors and it binds Cre 5'-GTGACGT[AC][AG]-3' a sequence which is present in several cellular as well as viral promoters. ATF3 exerts its repressive effects on transcription from promoters with ATF sites by stabilizing the binding of inhibitory cofactors of target promoters. Expressed by various cell types with nuclear localization, ATF3 expression gets upregulated by a variety of extracellular stimuli such as cytokines, chemokines, growth factors, hormones, hypoxia, DNA damage, ER stress and starvation. Originally considered a stress-response gene, ATF3 now has emerged as a factor implicated in general adaptive responses such as environmental, emotional and nutritional alterations. Its disorders have been associated with inflammatory and immune diseases as well as cancer, and unlike other ATF/CREB family members, ATF3 is emerging as a factor involved in protection against malignant cells and invading pathogens.
Synonyms	activating transcription factor 3; ATF3deltaZip2; ATF3deltaZip2c; ATF3deltaZip3; OTTHUMP00000034887; OTTHUMP00000034890
Note	This ATF3 antibody is useful for Western Blot, ELISA and Immunohistochemistry paraffin embedded sections.
Reference Data
Protein Families	Transcription Factors

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