DRP1 (DNM1L) Mouse Monoclonal Antibody [Clone ID: 4E11B11]

Specifications

Product Data
Clone Name	4E11B11
Applications	ELISA, IHC, WB
Recommend Dilution	Immunohistochemistry: 1:200 - 1:1000, Immunohistochemistry-Paraffin: 1:200 - 1:1000, Western Blot: 1:500 - 1:2000, ELISA: 1:10000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Partial recombinant human DRP1 (between residues 100-250) expressed in E. coli. [UniProt O00429]
Isotype	IgG1
Formulation	PBS, 0.03% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Ammonium sulfate precipitation
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	dynamin 1-like
Database Link	NP_036192 Entrez Gene 10059 Human UniProt ID O00429
Background	A human dynamin-related protein, DRP1 contributes to mitochondrial division in mammalian cells. It plays this important role in mitochondrial fission at steady state and during apoptosis. DRP1 is required for proper cellular distribution of mitochondria, and in mutant neurons, mitochondria are largely absent from synapses, thus providing a genetic tool to assess the role of mitochondria at synapses.
Synonyms	DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1; HDYNIV
Reference Data
Protein Pathways	Endocytosis, Fc gamma R-mediated phagocytosis

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