NLRX1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry, Western Blot: 5-7ug/ml~, Immunohistochemistry-Paraffin: 5-10ug/ml
Reactivity	Human, Mouse, Rat, Equine, Primate
Host	Rabbit
Clonality	Polyclonal
Immunogen	A portion of amino acid 580-630 of human NLRX1 was used as the immunogen for the antibody.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein A purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	NLR family member X1
Database Link	NP_078894 Entrez Gene 270151 MouseEntrez Gene 315599 RatEntrez Gene 79671 Human UniProt ID Q86UT6
Background	NLR family member X1 (NLRX1) belongs to the NLRP family and contains four LRR (leucine-rich) repeats and one NATCH domain. NLRX1 localizes to the mitochondrial outer membrane and interacts through the mitochondrial antiviral signalling adaptor MAVS during viral infection. Expression of NLRX1 results in the potent inhibition of RLH- and MAVS-mediated interferon-beta promoter activity and in the disruption of virus-induced RLH-MAVS interactions. It is also reported that NLRX1 synergistically potentiated ROS production induced by tumour necrosis factor alpha, Shigella infection and double-stranded RNA, resulting in amplified NF-kappaB-dependent and JUN amino-terminal kinases-dependent signalling, thus contributing to the link between ROS generation at the mitochondria and innate immune responses.
Synonyms	CLR11.3; DLNB26; NOD5; NOD9; NOD26
Reference Data
Protein Pathways	RIG-I-like receptor signaling pathway

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