GPR183 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry, Immunohistochemistry-Paraffin: 5ug/ml, Western Blot: 2-4ug/ml~
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A portion of amino acids 300-350 of human EBI2 was used as the immunogen.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at -20C. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein A purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	G protein-coupled receptor 183
Database Link	NP_004942 Entrez Gene 1880 Human UniProt ID P32249
Background	G-protein coupled receptor 183 (EBI2) belongs to the G-protein coupled receptor 1 family of proteins. It is an orphan seven-transmembrane receptor originally identified as most up-regulated gene (>200-fold) in EBV-infected cells. It plays a central role during humoral immunity. It promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses. It is expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes. It is also reported to be highly expressed in lung, heart and gastrointestinal tract. EBI2 deficiency in mice led to a reduction in the early antibody response to a T-dependent antigen.
Synonyms	EBI2; hEBI2
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane

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