ATP citrate lyase (ACLY) Mouse Monoclonal Antibody [Clone ID: 3D9-E9-H8]

Specifications

Product Data
Clone Name	3D9-E9-H8
Applications	FC, IF, WB
Recommend Dilution	WB: 1:1000, IF: 1:150, FC: 1:100
Reactivity	Human, Monkey, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for ACLY antibody: purified recombinant human ATP-Citrate Lyase protein fragments expressed in E.coli.
Isotype	IgG2a
Formulation	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	120 kDa
Gene Name	ATP citrate lyase
Database Link	NP_001087 Entrez Gene 104112 MouseEntrez Gene 47 Human UniProt ID P53396
Background	ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.
Synonyms	ACL; ATPCL; CLATP
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Citrate cycle (TCA cycle), Metabolic pathways

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