ATIC Mouse Monoclonal Antibody [Clone ID: 3H12-C9-H9]

Specifications

Product Data
Clone Name	3H12-C9-H9
Applications	WB
Recommend Dilution	WB: 1:1000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for ATIC antibody: purified recombinant human ATIC protein fragments expressed in E.coli.
Isotype	IgG1
Formulation	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	64 kDa
Gene Name	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Database Link	NP_004035 Entrez Gene 81643 RatEntrez Gene 108147 MouseEntrez Gene 471 Human UniProt ID P31939
Background	This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.
Synonyms	AICAR; AICARFT; HEL-S-70p; IMPCHASE; PURH
Reference Data
Protein Families	Stem cell - Pluripotency
Protein Pathways	Metabolic pathways, One carbon pool by folate, Purine metabolism

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