HP1 alpha (CBX5) Mouse Monoclonal Antibody [Clone ID: 3G2-H10-A6]

Specifications

Product Data
Clone Name	3G2-H10-A6
Applications	IF, IHC, WB
Recommend Dilution	WB: 1:1000, IF: 1:300
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for CBX5 antibody: purified recombinant human HP1 alpha protein fragments expressed in E.coli.
Isotype	IgG2b
Formulation	Purified mouse monoclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	26 kDa
Gene Name	chromobox 5
Database Link	NP_036249 Entrez Gene 12419 MouseEntrez Gene 23468 Human UniProt ID P45973
Background	This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Synonyms	HEL25; HP1; HP1A
Reference Data

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