Cyclin H (CCNH) Mouse Monoclonal Antibody [Clone ID: 4E11-G2-D7]

Specifications

Product Data
Clone Name	4E11-G2-D7
Applications	IP, WB
Recommend Dilution	WB: 1:1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for CCNH antibody: purified recombinant human Cyclin H protein fragments expressed in E.coli.
Isotype	IgG2b
Formulation	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50% glycerol
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	38 kDa
Gene Name	cyclin H
Database Link	NP_001230 Entrez Gene 902 Human UniProt ID P51946
Background	The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[
Synonyms	CAK; CycH; p34; p37
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Cell cycle, Nucleotide excision repair

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