smooth muscle Myosin heavy chain 11 (MYH11) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	ChIP/ChIP-seq (5ul/ChIP); ELISA (1:200); Western blotting (1:1,000)
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-MYH11 antibody: human MYH11 (Myosin, Heavy Chain 11) using two KLH-conjugated synthetic peptides containing sequences from the C-terminal region of the protein.
Isotype	IgG
Concentration	lot specific
Purification	Whole antiserum from rabbit containing 0.05% azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	myosin, heavy chain 11, smooth muscle
Database Link	NP_001035203 Entrez Gene 4629 Human UniProt ID P35749
Background	MYH11 (UniProtKB/Swiss-Prot entry P35749) is a smooth muscle myosin belonging to the myosin heavy chain family which function as major contractile proteins. MYH11 is involved in a pericentric inversion of chromosome 16 (inv(16)(p13q22)) which produces a chimeric transcript consisting of the N terminus of CBFb andthe C-terminal portion MYH11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype.
Synonyms	AAT4; FAA4; SMHC; SMMHC
Reference Data
Protein Pathways	Tight junction, Vascular smooth muscle contraction, Viral myocarditis

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