RFXAP Rabbit Polyclonal Antibody

Specifications

Product Data
Recommend Dilution	ChIP (5-7 µg/IP)
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-RFX-AP antibody: RFXAP (Regulatory factor X-associated protein), using the recombinant protein.
Isotype	IgG
Concentration	lot specific
Purification	Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	regulatory factor X associated protein
Database Link	NP_000529 Entrez Gene 5994 Human UniProt ID O00287
Background	RFXAP (UniProtKB/Swiss-Prot entry O00287) is part of the RFX complex that binds to the X-box of MHC II promoters. The RFX complex consists of at least 3 different subunits; RFXAP, RFX5 and RFX-B/RFXANK; with each subunit representing a separate complementation group. RFX forms cooperative DNA binding complexes with X2BP and CBF/NF-Y. RFX associates with CIITA to form an active transcriptional complex. Defects in RFXAP can cause bare lymphocyte syndrome type II (BLS II); also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency.
Synonyms	RFXAP
Reference Data
Protein Families	Transcription Factors
Protein Pathways	Antigen processing and presentation, Primary immunodeficiency

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