Cyclin A1 (CCNA1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:3000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-Cyclin A1 Antibody: A synthesized peptide derived from human Cyclin A1
Isotype	IgG
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Affinity-chromatography
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	52 kDa
Gene Name	cyclin A1
Database Link	NP_003905 Entrez Gene 12427 MouseEntrez Gene 295052 RatEntrez Gene 8900 Human UniProt ID P78396
Background	CCNA1 May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. Belongs to the cyclin family. Cyclin AB subfamily. Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins.
Synonyms	CT146
Note	Cyclin A1 antibody detects endogenous levels of total Cyclin A1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Acute myeloid leukemia, Cell cycle, Pathways in cancer, Progesterone-mediated oocyte maturation

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