TWIST2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-Twist2 Antibody: Peptide sequence around aa.26~30(P-K-R-F-G) derived from Human Twist2.
Isotype	IgG
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?.Stable for 12 months from date of receipt
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	18kd
Gene Name	twist family bHLH transcription factor 2
Database Link	NP_476527 Entrez Gene 13345 MouseEntrez Gene 59327 RatEntrez Gene 117581 Human UniProt ID Q8WVJ9
Background	Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.
Synonyms	AMS; BBRSAY; bHLHa39; DERMO1; FFDD3; SETLSS
Note	The antibody detects endogenous level of total Twist2 protein.
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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