OASL Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 2.5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	OASL antibody was raised against a 17 amino acid peptide near the amino terminus of human OASL.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	OASL antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 57 kDa; Observed: 65 kDa
Gene Name	2'-5'-oligoadenylate synthetase like
Database Link	NP_003724 Entrez Gene 8638 Human UniProt ID Q15646
Background	OASL (2'-5'-oligoadenylate synthetase-like), also known as p59OASL or TRIP14 (thyroid receptor-interacting protein 14), is a 514 amino acid protein that exists as two alternatively spliced isoforms, designated p56 and p30, and contains two ubiquitin-like domains (1). It is widely expressed in a variety of tissues and interacts with the ligand binding domain of the thyroid receptor (TR) and is able to bind double-stranded RNA and DNA, possibly playing a role in RNA degradation and the overall inhibition of protein synthesis (2-3). Methyl CpG-binding protein 1 (MBD1), which functions as a transcriptional repressor, was identified as a strong p59 OASL interactor (4).
Synonyms	DRP; DRP1; SMAP-3
Reference Data

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