PINK1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	PINK1 antibody was raised against a 16 amino acid peptide near the amino terminus of human PINK1.
Isotype	IgG
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	PINK1 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 55 kDa; Observed: 53 kDa
Gene Name	PTEN induced putative kinase 1
Database Link	NP_115785 Entrez Gene 68943 MouseEntrez Gene 298575 RatEntrez Gene 65018 Human UniProt ID Q9BXM7
Background	The PTEN-induced putative kinase 1 (PINK1) is a serine/threonine protein kinase that localizes to mitochondria and is thought to protect cells from stress-induced mitochondrial dysfunction (reviewed in 1). PINK1 recruits the E3 ubiquitin ligase Parkin to mitochondria to initiate mitophagy, an autophagic process that clears damaged mitochondria within a cell (2). PINK1 is cleaved by the mitochondrial protease PARL (3). Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease (4).
Synonyms	BRPK; PARK6
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Parkinson's disease

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