BAMBI Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	BAMBI antibody was raised against a 17 amino acid peptide near the center of human BAMBI.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	BAMBI antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 29 kDa; Observed: 26 kDa
Gene Name	BMP and activin membrane-bound inhibitor
Database Link	NP_036474 Entrez Gene 68010 MouseEntrez Gene 83837 RatEntrez Gene 25805 Human UniProt ID Q13145
Background	BAMBI (BMP and activin membrane-bound inhibitor homolog, NMA) is a membrane spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development (1). BAMBI transcription regulation is under the influence of beta-catenin, BMP, smad3 and smad4 (2,3). BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues (4). BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines (5).
Synonyms	NMA
Reference Data
Protein Families	Transmembrane

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