THOC7 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Mouse spleen and human fetal liver tissue, hela cells and mouse testis tissue, A431 cells IHC: 25-100 Positive control: Human lung cancer Predicted cell location: Nucleus
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human THOC7
Isotype	IgG
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	24 kDa
Gene Name	THO complex 7
Database Link	NP_079351 Entrez Gene 80145 Human UniProt ID Q6I9Y2
Background	NIF3L1 BP1 (Ngg1-interacting factor 3-like 1 binding protein 1), also known as THOC7 (THO complex subunit 7 homolog), fSAP24 or hTREX30, is a 204 amino acid cytoplasmic and nuclear protein that belongs to the THOC7 family and interacts with NIF3L1. NIF3L1 BP1 is a component of the THO/TREX complex that is recruited to transcribed genes and travels along with RNA polymerase II (Pol II) during elongation, coupling Pol II with RNA splicing and export factors. The THO/TREX complex also plays a role in the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The gene that encodes NIF3L1 BP1 maps to human chromosome 3p14.1.
Synonyms	fSAP24; hTREX30; NIF3L1BP1
Reference Data

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