gp340 (DMBT1) Rabbit Polyclonal Antibody
CAT＃: TA350650S
Rabbit Polyclonal Anti-DMBT1 Antibody
Size: 100 ul
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CNY 800.00
CNY 1280.00
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CNY 300.00
CNY 1430.00
Specifications
| Product Data | |
| Applications | IHC |
| Recommend Dilution | IHC: 50-100 Positive control: Human gastric cancer Predicted cell location: Secreted |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human DMBT1 |
| Isotype | IgG |
| Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Gene Name | deleted in malignant brain tumors 1 |
| Database Link | |
| Background | Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. |
| Synonyms | GP340; muclin; SAG; SALSA |
| Reference Data | |
| Protein Families | Druggable Genome |
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