l Afadin (AFDN) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human colon cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide of human MLLT4
Isotype	IgG
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4
Database Link	NP_005927 Entrez Gene 17356 MouseEntrez Gene 26955 RatEntrez Gene 4301 Human UniProt ID P55196
Background	This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.
Synonyms	AF-6; AF6; AFADIN; FLJ34371; RP3-431P23.3
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Adherens junction, Leukocyte transendothelial migration, Tight junction

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