TIMP4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Rat, Mouse, Bovine
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to C-term of human TIMP-4. This sequence is identical among human, rat, mouse, chicken, dog and bovine.
Isotype	IgG
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	25 kDa
Gene Name	TIMP metallopeptidase inhibitor 4
Database Link	NP_003247 Entrez Gene 110595 MouseEntrez Gene 680130 RatEntrez Gene 7079 Human UniProt ID Q99727
Background	Tissue Inhibitors of Metalloproteinases (TIMPs) inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMPs comprise a family of four members: TIMP1, 2, 3, 4. TIMP-1 and TIMP-2 have similar properties, while TIMP-3 and TIMP-4 are involved inflammation-induced apoptosis and in matrix turnover. TIMP-4 is overexpressed in pilocytic astrocytomas, cardiovascular tissue areas populated by abundant inflammatory cells, human blood derived lymphocytes, monocytes/macrophages and mast cells. The TIMP-4 and its putative partner CD63 are potential markers of the astroctic phenotype in patients with gliomas.
Synonyms	TIMP metallopeptidase inhibitor 4; tissue inhibitor of metalloproteinase 4
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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