SAMHD1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: at 0.5-1µg/ml.IHC starting at 2.5µg/mL. IF start at 20µg/mL.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Phospho-SAMHD1 antibody was raised against a phosphorylated 18 amino acid peptide near the carboxy terminus of human Phospho-SAMHD1 surrounding T592.
Isotype	IgG
Formulation	SAMHD1 (phospho Thr592) antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	SAMHD1 (phospho Thr592) antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 69 kDa
Gene Name	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
Database Link	NP_056289 Entrez Gene 25939 Human UniProt ID Q9Y3Z3
Background	The SAM domain and HD domain 1 (SAMHD1) protein is upregulated in response to viral infection and is thought to play a role in innate immunity (1). SAMHD1 blocks the infection of HIV-1 and SIVdeltaVpx before reverse transcription in macrophages and dendritic cells (2), and this restriction is regulated by phosphorylation of SAMHD1 (3). Mutations in this gene have been associated with Aicardi-Goutieres syndrome (1).
Synonyms	AGS5; DCIP; HDDC1; Mg11; MOP-5; MOP5; SBBI88
Note	SAMHD1 (phospho Thr592) antibody can be used for detection of SAMHD1 (phospho Thr592) by western blot at at 0.5 - 1 µg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Reference Data

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