B7-1 (CD80) Mouse Monoclonal Antibody [Clone ID: 7A2]

CAT#: TA355076

Mouse Monoclonal Anti-CD80 Antibody [7A2]



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CNY 6,861.00


货期*
5周

规格
    • 100 ug

经常一起买 (2)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

CNY 300.00
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Recombinant protein of human CD80 molecule (CD80), 100 µg
    • 100 ug

CNY 9,998.00

Specifications

Product Data
Clone Name 7A2
Applications IF, IHC
Recommend Dilution IHC starting at 2-5µg/mL.IF start at 5µg/mL. FC: 10µg/ml.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen CD80 antibody was raised against the extracellular domain of human CD80.
Formulation CD80 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification CD80 Antibody is supplied as protein A purified IgG1.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size Predicted: 32 kDa; Observed: 50 kDa
Gene Name CD80 molecule
Background CD80 Antibody: CD80, also known as B7-1, is a type I membrane protein that is a member of the immunoglobulin superfamily. Like the related protein CD86, this protein is expressed by antigen-presenting cells, and is the ligand for two proteins at the cell surface of T cells, CD28 and the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell and induces T-cell proliferation and cytokine production. CTLA-4 binding negatively regulates T-cell activation and diminishes the immune response (1). Blocking the CTLA-4-CD80/CD86 interaction has been shown to enhance T-cell functions in acute lymphoblastomic leukemia (ALL), suggesting that this pathway may be an attractive target for future cancer immunotherapy (2).
Synonyms B7; BB1; CD28LG; CD28LG1; LAB7
Note CD80 antibody can be used for immunohistochemistry starting at 2 - 5 µg/mL. For immunofluorescence start at 5 µg/mL. Flow cytometry at 10 µg/ml.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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