CD38 Rabbit Monoclonal Antibody [Clone ID: DM28]

Specifications

Product Data
Clone Name	DM28
Applications	ELISA, FC
Recommend Dilution	ELISA 1/5000-10000; Flow Cyt  1/100
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	Recombinant human CD38 (Val43-IIe300)(TP723927) produced by using human HEK293 cells
Isotype	IgG
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization. Preservative: 0.1% Procline 300
Reconstitution Method	Reconstitute with deionized water
Purification	Purified from cell culture supernatant by affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store at -20°C for 12 months (Avoid repeated freezing and thawing)
Predicted Protein Size	34kDa
Gene Name	CD38 molecule
Database Link	Entrez Gene 952 Human UniProt ID P28907
Background	CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.
Synonyms	T10
Reference Data

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