bcl 6 (BCL6) Mouse Monoclonal Antibody [Clone ID: LN22]

Specifications

Product Data
Clone Name	LN22
Applications	IHC
Recommend Dilution	1:60
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein containing 1–350 amino acids of the N-terminus of the Bcl-6 human oncoprotein molecule
Specificity	Human Bcl-6 oncoprotein
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	B-cell CLL/lymphoma 6
Database Link	Entrez Gene 604 Human UniProt ID P41182
Background	Bcl-6 is a proto-oncogene that encodes a Kruppel-type zinc-finger protein of 95 kD and shares homology with other transcription factors. Bcl-6 protein is mainly expressed in normal germinal center B cells and related lymphomas. It has been shown that the Bcl-6 proto-oncogene is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have also been detected in 33-45% of diffuse large B cell lymphomas. Immunohistochemistry has been reported to show the Bcl-6 gene product to be detectable in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.
Synonyms	BCL-5; BCL-6; BCL5; BCL6A; LAZ3; ZBTB27; ZNF51
Reference Data

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