Oct4 (POU5F1) Mouse Monoclonal Antibody [Clone ID: N1NK]

Specifications

Product Data
Clone Name	N1NK
Applications	IHC
Recommend Dilution	1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein corresponding to 147 amino acids of the N-terminus of the human Oct-3/4 molecule
Specificity	Human Oct-3/4
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	POU class 5 homeobox 1
Database Link	Entrez Gene 5460 Human UniProt ID Q01860
Background	Oct-3/4 is a member of the POU homeodomain family of transcription factors, which is expressed by embryonic stem cells and germ cells. A critical amount of Oct-3/4 is required to maintain stem cell self replication. Down regulation of Oct-3/4 levels are associated with loss of pluripotency. Oct-3/4 has been proposed as a useful marker for germ cell tumors which exhibit features of pluripotentiality, including seminoma/dysgerminoma/germinoma and embryonal carcinoma, and establishing a germ cell origin for some metastatic tumors of uncertain primary origin.
Synonyms	MGC22487; Oct-3; Oct-4; OCT3; OCT4; OTF3; OTF4
Reference Data

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