PION (GSAP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen is a synthetic peptide directed towards the N-terminal region of Human GSAP
Specificity	Expected reactivity: Cow, Dog, Horse, Human, Rabbit, Rat Homology: Cow: 85%; Dog: 85%; Horse: 93%; Human: 100%; Rabbit: 93%; Rat: 86%
Formulation	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration	lot specific
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted Protein Size	93kDa
Gene Name	gamma-secretase activating protein
Database Link	NP_059135 Entrez Gene 54103 Human UniProt ID A4D1B5
Background	Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease. Formation of amyloid-beta is catalyzed by gamma-secretase, a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein C-terminal fragment (APP-CTF).
Synonyms	PION
Reference Data

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