PACAP (ADCYAP1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	This antibody has been tested and validated in ELISA against PACAP- 38. Other applications like immunohistochemistry (IHC), FACS or Western Blot may work as well. Optimal dilutions should be determined by the end user.
Reactivity	Human, Chicken, Mouse, Porcine, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg- Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys- Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2 coupled to carrier protein.
Formulation	Protein A affinity purified from antiserum, lyophilized, packaged under nitrogen. Reconstitute by adding 0.2ml distilled water. This stock solution contains 2mg/ml IgG, phosphate buffer saline pH 7.4 (PBS), and 0.02% (w/v) Thimerosal as a preservative.
Concentration	N/A
Conjugation	Unconjugated
Storage Condition	Original vial: at least one year at 4° - 8°C from date of delivery. Minimize repeated thawing and freezing of the antiserum by freezing aliquots at -20°C or below.
Gene Name	adenylate cyclase activating polypeptide 1
Database Link	Entrez Gene 116 Human UniProt ID P18509
Background	Pituitary Adenylate Cyclase-Activating Polypeptide-38, also known as PACAP-38, is a 38 amino acid neuropeptide that has substantial sequence homology (68%) to vasoactive intestinal peptide (VIP). It derives from a 176-amino acid precursor (preproPACAP), and it was discovered as an ovine hypothalamic neuropeptide. PACAP-38 is reported to serve as a neuronal survival factor and it has a greater potency for stimulation of adenylyl cyclase. Also, it stimulates insulin secretion from islets in a glucose-dependent manner at femtomolar concentrations, acting as an insulinotropic factor. This antibody was generated by immunization of rabbits with PACAP-38 coupled to a carrier protein.
Synonyms	MGC126852; OTTHUMP00000162201; PACAP
Reference Data

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