RNF20 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Hela, Jurkat, 231, A375, A172 and Lovo cells IHC: 10-50 Positive control: Human esophagus cancer Predicted cell location: Nucleus
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human RNF20
Isotype	IgG
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Predicted Protein Size	114 kDa
Gene Name	ring finger protein 20
Database Link	Entrez Gene 56254 Human UniProt ID Q5VTR2
Background	The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor.
Synonyms	BRE1; BRE1-A; BRE1A; FLJ11189; FLJ20382; hBRE1; KAIA2779; KIAA2779; MGC129667; MGC129668
Reference Data

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