MAGEB5 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human brain Predicted cell location: Cytoplasm and Cell membrane
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide of human MAGEB5
Isotype	IgG
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Gene Name	MAGE family member B5
Database Link	Entrez Gene 347541 Human UniProt ID Q9BZ81
Background	The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors and, based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. MAGE genes encode for tumor-rejection antigens that are expressed in tumors of different histologic types and in normal testis and placenta. MAGE-B5 (melanoma-associated antigen B5), also known as CT3.3 (cancer/testis antigen 3.3), is a 275 amino acid protein that contains one MAGE domain and is expressed in testis. The gene encoding MAGE-B5 maps to human chromosome X, which consists of about 153 million base pairs and nearly 1,000 genes. Color blindness, hemophilia and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently, as males carry a single X chromosome.
Synonyms	CT3.3; MAGE-B5
Reference Data

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