ZGPAT Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: Human fetal liver tissue, LO2 cell, PC-3 cell, HEPG2 cell lysates IHC: 50-300 Positive control: Human ovarian cancer Predicted cell location: Nucleus
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human ZGPAT
Isotype	IgG
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Predicted Protein Size	57 kDa
Gene Name	zinc finger CCCH-type and G-patch domain containing
Database Link	Entrez Gene 84619 Human UniProt ID Q8N5A5
Background	Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.
Synonyms	dJ583P15.3; FLJ14972; GPATC6; GPATCH6; KIAA1847; MGC44880; ZC3H9; ZC3HDC9; ZIP
Reference Data

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