BCCIP Rabbit Polyclonal Antibody
CAT#: TA373960
BCCIP Rabbit polyclonal Antibody
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货期*
2周
规格
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Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | WB,1:500 - 1:2000 IHC,1:100 - 1:200 |
Reactivity | Human, Mouse, Rat |
Modifications | Unmodified |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-314 of human BCCIP (NP_510868.1). |
Formulation | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20℃. Avoid freeze / thaw cycles. |
Predicted Protein Size | 33kDa/35kDa/36kDa |
Gene Name | BRCA2 and CDKN1A interacting protein |
Database Link | |
Background | This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. |
Synonyms | BCCIPalpha; BCCIPbeta; TOK-1; TOK-1alpha; TOK-1beta; TOK1 |
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