CBL Rabbit Polyclonal Antibody

CAT#: TA374317

Phospho-CBL-Y700 Rabbit polyclonal Antibody

Size: 20 ul 100 ul



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CNY 2900.00


货期*
2周

规格
    • 100 ul

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Specifications

Product Data
Applications ELISA, WB
Recommend Dilution WB,1:500 - 1:2000
ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Reactivity Human
Modifications Phospho Y700
Host Rabbit
Clonality Polyclonal
Isotype IgG
Formulation Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Condition Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size 100kDa
Gene Name Cbl proto-oncogene
Background This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
Synonyms C-CBL; CBL2; RNF55
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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