FGD4 Rabbit Polyclonal Antibody
CAT#: TA376216
FGD4 Rabbit polyclonal Antibody
Size: 20 ul
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CNY 1999.00
CNY 3280.00
CNY 300.00
CNY 1430.00
Specifications
Product Data | |
Applications | ELISA, WB |
Recommend Dilution | WB,1:500 - 1:2000 ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. |
Reactivity | Human, Mouse, Rat |
Modifications | Unmodified |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Formulation | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20℃. Avoid freeze / thaw cycles. |
Predicted Protein Size | 87kDa |
Gene Name | FYVE, RhoGEF and PH domain containing 4 |
Database Link | |
Background | This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Synonyms | CMT4H; DKFZp313E1818; DKFZp434K1572; FLJ34370; FLJ42663; frabin; FRABP; MGC57222; ZFYVE6 |
Reference Data |
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