Havcr2 Rabbit Polyclonal Antibody
CNY 1,999.00
CNY 3,280.00
货期*
2周
规格
经常一起买 (1)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB,1:500 - 1:2000 |
Reactivity | Human, Mouse, Rat |
Modifications | Unmodified |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Recombinant protein of Mouse HAVCR2. |
Formulation | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20℃. Avoid freeze / thaw cycles. |
Predicted Protein Size | 30kDa |
Gene Name | hepatitis A virus cellular receptor 2 |
Database Link | |
Background | T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), isa transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important rolein the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, anddendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosisof apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interactionwith phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressivefunctions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with anagonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is alsoregarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as twoimportant coinhibitory regulators of T cell responses, have been implicated with the T-cell dysfunction orexhaustion associated with chronic HBV infection including HBV-related HCC. |
Synonyms | FLJ14428; HAVcr-2; KIM-3; Tim-3; TIM3; TIMD-3; TIMD3 |
Reference Data |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
Customer
Reviews
Loading...