BCL2 Rabbit Monoclonal Antibody [Clone ID: R07-2A1]

Specifications

Product Data
Clone Name	R07-2A1
Applications	IHC, WB
Recommend Dilution	WB: 1/1000 IHC: 1/20-1/500
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Monoclonal
Immunogen	Recombinant protein of human Bcl-2
Isotype	IgG
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 26 kDa; Observed MW: 26 kDa
Gene Name	B-cell CLL/lymphoma 2
Database Link	Entrez Gene 596 Human UniProt ID P10415
Background	Swiss-Prot Acc.P10415.Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
Synonyms	Bcl-2; OTTHUMP00000163680
Reference Data

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